Non-Sedating Histamine H1 Antagonists

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.

Also Known As:

Histamine H1 Antagonists, Non Sedating; Histamine H1 Antagonists, Non-Sedating; H1 Antihistamines, Non-Sedating; Second Generation Antihistamines; Second Generation H1 Antagonists; Third Generation H1 Antagonists; Antihistamine, Second Generation; Antihistamines, Second Generation; Generation Antihistamine, Second; H1 Antihistamines, Non Sedating; Non-Sedating H1 Antihistamines; Second Generation Antihistamine; Second Generation H1 Antagonist; Third Generation H1 Antagonist

Chemical Actions and Uses
- Pharmacologic Actions: 164
  - Molecular Mechanisms of Pharmacological Action: 26
    - Neurotransmitter Agents: 13574
      - Histamine Agents: 78
        Histamine Antagonists: 4829
        Histamine H1 Antagonists: 219
        Non-Sedating Histamine H1 Antagonists: 223
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 13574
      - Histamine Agents: 78
        Histamine Antagonists: 4829
        Histamine H1 Antagonists: 219
        Non-Sedating Histamine H1 Antagonists: 223

Mariko Niide Selected Research

Mariko Niide Research Topics

Disease

Drug/Important Bio-Agent (IBA)